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1

Discovery and structure–activity study of a novel benzoxaborole anti-inflammatory agent (AN2728) for the potential topical treatment of psoriasis and atopic dermatitis

Tsutomu Akama, Stephen J. Baker, Yong-Kang Zhang, Vincent Hernandez, Huchen Zhou, Virginia Sanders, Yvonne Freund, Richard Kimura, Kirk R. Maples, Jacob J. Plattner

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 434 KB

english, 2009

2

General theory of cosmological perturbations in open and closed universes from the Horndeski action

Akama, Shingo, Kobayashi, Tsutomu

Journal:

Physical Review D

Year:

2019

Language:

english

File:

PDF, 247 KB

english, 2019

3

Synthesis of isotopically labelled [3-14C]- and [3,3-2H2]-5-fluoro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole (AN2690), a new antifungal agent for the potential treatment of onychomycosis

Stephen J. Baker, Yong-Kang Zhang, Tsutomu Akama, Conrad Wheeler, Jacob J. Plattner, Richard M. Rosser, Ronald P. Reid, Neil S. Nixon

Journal:

Journal of Labelled Compounds and Radiopharmaceuticals

Year:

2007

Language:

english

File:

PDF, 113 KB

english, 2007

4

Early rapid identification of in vivo rat metabolites of AN6414, a novel boron-containing PDE4 inhibitor by QTRAP LC/MS/MS to support drug discovery

Wei Bu, Tsutomu Akama, Sanjay Chanda, David Sullivan, Vic Ciaravino, Kurt Jarnagin, Yvonne Freund, Virginia Sanders, Chiao-Wen Chen, Xiaoqing Fan, Irwin Heyman, Liang Liu

Journal:

Journal of Pharmaceutical and Biomedical Analysis

Year:

2012

Language:

english

File:

PDF, 1.27 MB

english, 2012

5

Discovery of a New Boron-Containing Antifungal Agent, 5-Fluoro-1,3-dihydro-1-hydroxy-2,1- benzoxaborole (AN2690), for the Potential Treatment of Onychomycosis

Baker, Stephen J., Zhang, Yong-Kang, Akama, Tsutomu, Lau, Agnes, Zhou, Huchen, Hernandez, Vincent, Mao, Weimin, Alley, M. R. K., Sanders, Virginia, Plattner, Jacob J.

Journal:

Journal of Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 66 KB

english, 2006

6

Structure–activity relationships of 6-(aminomethylphenoxy)-benzoxaborole derivatives as anti-inflammatory agent

Akama, Tsutomu, Virtucio, Charlotte, Dong, Chen, Kimura, Richard, Zhang, Yong-Kang, Nieman, James A., Sharma, Rashmi, Lu, Xiaosong, Sales, Marcelo, Singh, Rajeshwar, Wu, Anne, Fan, Xiao-Qing, Liu, Lia

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 534 KB

english, 2013

7

Discovery and structure–activity relationships of 6-(benzoylamino)benzoxaboroles as orally active anti-inflammatory agents

Akama, Tsutomu, Dong, Chen, Virtucio, Charlotte, Freund, Yvonne R., Chen, Daitao, Orr, Matthew D., Jacobs, Robert T., Zhang, Yong-Kang, Hernandez, Vincent, Liu, Yang, Wu, Anne, Bu, Wei, Liu, Liang, Ja

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 626 KB

english, 2013

8

Identification of Borinic Esters as Inhibitors of Bacterial Cell Growth and Bacterial Methyltransferases, CcrM and MenH

Benkovic, Stephen J., Baker, Stephen J., Alley, M. R. K., Woo, Youn-Hi, Zhang, Yong-Kang, Akama, Tsutomu, Mao, Weimin, Baboval, Justin, Rajagopalan, P. T. Ravi, Wall, Mark, Kahng, Lyn Sue, Tavassoli,

Journal:

Journal of Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 261 KB

english, 2005

9

Discovery of an orally bioavailable isoxazoline benzoxaborole (AN8030) as a long acting animal ectoparasiticide

Zhang, Yong-Kang, Plattner, Jacob J., Easom, Eric E., Zhou, Yasheen, Akama, Tsutomu, Bu, Wei, White, W. Hunter, Defauw, Jean M., Winkle, Joseph R., Balko, Terry W., Guo, Shenghai, Xue, Jian, Cao, Jian

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 624 KB

english, 2015

10

Optimization of Isoxazoline Amide Benzoxaboroles for Identification of a Development Candidate as an Oral Long Acting Animal Ectoparasiticide

Zhang, Yong-Kang, Plattner, Jacob J., Easom, Eric E., Akama, Tsutomu, Zhou, Yasheen, Hunter White, W., Defauw, Jean M., Winkle, Joseph R., Balko, Terry W., Cao, Jianxin, Ge, Zhixin, Yang, Jianzhang

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2016

Language:

english

File:

PDF, 761 KB

english, 2016

11

Identification of a 4-fluorobenzyl l -valinate amide benzoxaborole ( AN11736 ) as a potential development candidate for the treatment of Animal African Trypanosomiasis (AAT)

Akama, Tsutomu, Zhang, Yong-Kang, Freund, Yvonne R., Berry, Pamela, Lee, Joanne, Easom, Eric E., Jacobs, Robert T., Plattner, Jacob J., Witty, Michael J., Peter, Rosemary, Rowan, Tim G., Gillingwater,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2017

Language:

english

File:

PDF, 981 KB

english, 2017

12

UCS1025A (I) and B (II), New Antitumor Antibiotics from the Fungus Acremonium Species

Tsutomu Agatsuma, Tsutomu Akama, Shinji Nara, Shigeki Matsumiya, Ryuichiro Nakai, Harumi Ogawa, Shizuo Otaki, Shun-ichi Ikeda, Yutaka Saitoh, Yutaka Kanda

Journal:

Year:

2003

File:

PDF, 95 KB

2003

13

ChemInform Abstract: Discovery and Structure—Activity Study of a Novel Benzoxaborole Antiinflammatory Agent (AN2728) for the Potential Topical Treatment of Psoriasis and Atopic Dermatitis.

Tsutomu Akama, Stephen J. Baker, Yong-Kang Zhang, Vincent Hernandez, Huchen Zhou, Virginia Sanders, Yvonne Freund, Richard Kimura, Kirk R. Maples, Jacob J. Plattner

Journal:

Year:

2009

File:

PDF, 21 KB

2009

14

In Vitro penetration of a novel oxaborole antifungal (AN2690) into the human nail plate

Xiaoying Hui, Stephen J. Baker, Ronald C. Wester, Sherry Barbadillo, Anne K. Cashmore, Virginia Sanders, Karin M. Hold, Tsutomu Akama, Yong-Kang Zhang, Jacob J. Plattner, Howard I. Maibach

Journal:

Journal of Pharmaceutical Sciences

Year:

2007

Language:

english

File:

PDF, 195 KB

english, 2007

15

Design and synthesis of boron-containing PDE4 inhibitors using soft-drug strategy for potential dermatologic anti-inflammatory application

Yong-Kang Zhang, Jacob J. Plattner, Tsutomu Akama, Stephen J. Baker, Vincent S. Hernandez, Virginia Sanders, Yvonne Freund, Richard Kimura, Wei Bu, Karin M. Hold, Xiao-Song Lu

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 642 KB

english, 2010

16

Identification of a novel boron-containing antibacterial agent (AN0128) with anti-inflammatory activity, for the potential treatment of cutaneous diseases

Stephen J. Baker, Tsutomu Akama, Yong-Kang Zhang, Vittorio Sauro, Chetan Pandit, Rajeshwar Singh, Maureen Kully, Jehangir Khan, Jacob J. Plattner, Stephen J. Benkovic, Ving Lee, Kirk R. Maples

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 143 KB

english, 2006

17

Memory impairment associated with a dysfunction of the hippocampal cholinergic system induced by prenatal and neonatal exposures to bisphenol-A

Kazuya Miyagawa, Minoru Narita, Michiko Narita, Hisahiko Akama, Tsutomu Suzuki

Journal:

Neuroscience Letters

Year:

2007

Language:

english

File:

PDF, 648 KB

english, 2007

18

Implantation-Dependent Expression of Trophinin by Maternal Fallopian Tube Epithelia during Tubal Pregnancies: Possible Role of Human Chorionic Gonadotrophin on Ectopic Pregnancy

Jun Nakayama, Daisuke Aoki, Tomoaki Suga, Tomoya O. Akama, Satoshi Ishizone, Hirohito Yamaguchi, Kazuhiko Imakawa, Daita Nadano, Asgerally T. Fazleabas, Tsutomu Katsuyama, Shiro Nozawa, Michiko N. Fuk

Journal:

The American Journal of Pathology

Year:

2003

Language:

english

File:

PDF, 1.07 MB

english, 2003

19

Design and Synthesis of Potent Antitumor 5,4‘-Diaminoflavone Derivatives Based on Metabolic Considerations

Akama, Tsutomu, Ishida, Hiroyuki, Shida, Yasushi, Kimura, Uichiro, Gomi, Katsushige, Saito, Hiromitsu, Fuse, Eiichi, Kobayashi, Satoshi, Yoda, Nobuyuki, Kasai, Masaji

Journal:

Journal of Medicinal Chemistry

Year:

1997

Language:

english

File:

PDF, 203 KB

english, 1997

20

Boron-based phosphodiesterase inhibitors show novel binding of boron to PDE4 bimetal center

Yvonne R. Freund, Tsutomu Akama, M.R.K. Alley, Joana Antunes, Chen Dong, Kurt Jarnagin, Richard Kimura, James A. Nieman, Kirk R. Maples, Jacob J. Plattner, Fernando Rock, Rashmi Sharma, Rajeshwar Sing

Journal:

Year:

2012

Language:

english

File:

PDF, 719 KB

english, 2012

21

Novel 5-Aminoflavone Derivatives as Specific Antitumor Agents in Breast Cancer

Akama, Tsutomu, Shida, Yasushi, Sugaya, Toru, Ishida, Hiroyuki, Gomi, Katsushige, Kasai, Masaji

Journal:

Journal of Medicinal Chemistry

Year:

1996

Language:

english

File:

PDF, 354 KB

english, 1996

22

Structure−Activity Relationships of the 7-Substituents of 5,4‘-Diamino-6,8,3‘-trifluoroflavone, a Potent Antitumor Agent

Akama, Tsutomu, Ishida, Hiroyuki, Kimura, Uichiro, Gomi, Katsushige, Saito, Hiromitsu

Journal:

Journal of Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 218 KB

english, 1998

23

UCS1025A and B, New Antitumor Antibiotics from the Fungus Acremonium Species

Agatsuma, Tsutomu, Akama, Tsutomu, Nara, Shinji, Matsumiya, Shigeki, Nakai, Ryuichiro, Ogawa, Harumi, Otaki, Shizuo, Ikeda, Shun-ichi, Saitoh, Yutaka, Kanda, Yutaka

Journal:

Organic Letters

Year:

2002

Language:

english

File:

PDF, 104 KB

english, 2002

24

Therapeutic potential of boron-containing compounds

Baker, Stephen J, Ding, Charles Z, Akama, Tsutomu, Zhang, Yong-Kang, Hernandez, Vincent, Xia, Yi

Journal:

Future Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 709 KB

english, 2009

25

Lewis acid assisted annelation of trimethylsilyl enol ethers of 1-acetylcyclohexenes with ?,?-unsaturated carbonyl compounds to give substituted 2-decalones; synthesis of (�)-?-cadinene

Hagiwara, Hisahiro, Okano, Akihiro, Akama, Tsutomu, Uda, Hisashi

Journal:

Journal of the Chemical Society Chemical Communications

Year:

1987

Language:

english

File:

PDF, 213 KB

english, 1987

26

Annulation by sequential double Michael reaction; synthesis of decalones and its application to the syntheses of ?-cadinene, khusitone and khusilal

Hagiwara, Hisahiro, Akama, Tsutomu, Okano, Akihiro, Uda, Hisashi

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

1993

Language:

english

File:

PDF, 1.76 MB

english, 1993

27

Synthesis of an Ethyl 6-Amino-3,5-difluorosalicylate Derivative by Sequential Regioselective Directed ortho-Metalation; A Practical Synthesis of4',5-Diamino-3',6,8-trifluoroflavone, A Potent Antitumor Agent

Akama, Tsutomu, Ueno, Kimihisa, Saito, Hiromitsu, Kasai, Masaji

Journal:

Year:

1997

File:

PDF, 445 KB

1997

28

A Novel CYP11B2-Specific Imaging Agent for Detection of Unilateral Subtypes of Primary Aldosteronism

Abe, Tsutomu, Naruse, Mitsuhide, Young, William F., Kobashi, Nobuya, Doi, Yoshihiro, Izawa, Akihiro, Akama, Kei, Okumura, Yuki, Ikenaga, Miho, Kimura, Hiroyuki, Saji, Hideo, Mukai, Kuniaki, Matsumoto,

Journal:

Journal of Clinical Endocrinology & Metabolism

Year:

2016

Language:

english

File:

PDF, 1.07 MB

english, 2016

29

Synthesis of Substituted 2-Decalones from 1-Acetylcyclohexenes and α-Trimethylsilyl α,β-Unsaturated Carbonyl Compounds by Two-Fold Michael Reactions. Synthesis of (±)-Khusitone

Hagiwara, Hisahiro, Akama, Tsutomu, Okano, Akihiro, Uda, Hisashi

Journal:

Chemistry Letters

Year:

1988

Language:

english

File:

PDF, 4.24 MB

english, 1988

30

Asymmetric Two-Fold Michael Reaction. Synthesis of Optically Active 4-Substituted 1-Decalones from Trimethylsilyl Enol Ether of 1-Acetylcyclohexene

Hagiwara, Hisahiro, Akama, Tsutomu, Okano, Akihiro, Uda, Hisashi

Journal:

Chemistry Letters

Year:

1989

File:

PDF, 308 KB

1989

31

A Synthesis of (±)-Khusilal

Hagiwara, Hisahiro, Akama, Tsutomu, Uda, Hisashi

Journal:

Chemistry Letters

Year:

1989

File:

PDF, 172 KB

1989

32

Generalized multi-Galileons, covariantized new terms, and the no-go theorem for nonsingular cosmologies

Akama, Shingo, Kobayashi, Tsutomu

Journal:

Physical Review D

Year:

2017

Language:

english

File:

PDF, 157 KB

english, 2017

33

Determination and Stability Studies of Urea in Urea Creams by High-Performance Liquid Chromatography

YASUDA, Tsutomu, AKAMA, Toshihiro, IKAWA, Hiroshi

Journal:

YAKUGAKU ZASSHI

Year:

1992

File:

PDF, 433 KB

1992

34

The DnaA AAA+ Domain His136 Residue Directs DnaB Replicative Helicase to the Unwound Region of the Replication Origin, oriC

Sakiyama, Yukari, Nishimura, Masahiro, Hayashi, Chihiro, Akama, Yusuke, Ozaki, Shogo, Katayama, Tsutomu

Journal:

Frontiers in Microbiology

Year:

2018

Language:

english

File:

PDF, 3.60 MB

english, 2018

35

General theory of cosmological perturbations in open and closed universes from the Horndeski action

Akama, Shingo, Kobayashi, Tsutomu

Journal:

Physical Review D

Year:

2019

File:

PDF, 247 KB

2019

36

Crystal structure of the complex of the interaction domains of E. coli DnaB helicase and DnaC helicase loader: Structural basis implying a distortion-accumulation mechanism for the DnaB ring opening caused by DnaC binding

Nagata, Koji, Okada, Akitoshi, Ohtsuka, Jun, Ohkuri, Takatoshi, Akama, Yusuke, Sakiyama, Yukari, Miyazaki, Erika, Horita, Shoichiro, Katayama, Tsutomu, Ueda, Tadashi, Tanokura, Masaru

Journal:

Journal of Biochemistry

Year:

2019

File:

PDF, 1.96 MB

2019

37

Macrofilaricidal Benzimidazole-Benzoxaborole Hybrids as an Approach to the Treatment of River Blindness. Part 2. Ketone Linked Analogs.

Carter, David S., Jacobs, Robert Toms, Freund, Yvonne, Berry, Pamela, Akama, Tsutomu, Easom, Eric E., Lunde, Christopher S., Rock, Fernando L., Stefanakis, Rianna, McKerrow, James H., Fischer, Chelsea

Journal:

ACS Infectious Diseases

Year:

2019

Language:

english

File:

PDF, 376 KB

english, 2019

38

Macrofilaricidal Benzimidazole-Benzoxaborole Hybrids as an Approach to the Treatment of River Blindness. Part 2. Ketone Linked Analogs.

Carter, David S., Jacobs, Robert Toms, Freund, Yvonne, Berry, Pamela, Akama, Tsutomu, Easom, Eric E., Lunde, Christopher S., Rock, Fernando L., Stefanakis, Rianna, McKerrow, James H., Fischer, Chelsea

Journal:

ACS Infectious Diseases

Year:

2019

File:

PDF, 376 KB

2019

39

Macrofilaricidal Benzimidazole-Benzoxaborole Hybrids as an Approach to the Treatment of River Blindness. Part 1. Amide Linked Analogs.

Akama, Tsutomu, Freund, Yvonne T., Berry, Pamela, Carter, David S., Easom, Eric E., Jarnagin, Kurt, Lunde, Christopher S., Plattner, Jacob J., Rock, Fernando, Stefanakis, Rianna, Fischer, Chelsea, Bul

Journal:

ACS Infectious Diseases

Year:

2019

File:

PDF, 304 KB

2019

40

Primordial tensor non-Gaussianities from general single-field inflation with non-Bunch-Davies initial states

Akama, Shingo, Hirano, Shinâichi, Kobayashi, Tsutomu

Journal:

Physical Review D

Year:

2020

File:

PDF, 225 KB

2020

41

Primordial non-Gaussianities of scalar and tensor perturbations in general bounce cosmology: Evading the no-go theorem

Akama, Shingo, Hirano, Shinâichi, Kobayashi, Tsutomu

Journal:

Physical Review D

Year:

2020

File:

PDF, 1.15 MB

2020